ישראל הרשקוביץ

Diploic veins (Canales diploicae), which were identified in dogs by Dupuytren more than 200 years ago (Hecker [1845] Die anatomische Verhaltnisse und Krankheiten der Venae diploicae und Vasa emissaria. Erfahrungen und Abhandlungen im Gebiete der Chirurgie und Augenheilkunde. Erlangen), have remained inadequately understood and scantily referenced in the anatomical and anthropological literature. The tunnels formed by diploic veins are among the few known skeletal markers of soft tissue alteration. Protected by two bony laminae, diploic vein tunnels often resist postdepositional destruction and may provide a new way to assess living and extinct hominid populations. This basic research was carried out to enable future utilization of the diploic venous channels in anthropologic research. In the present study, diploic venous channels were observed radiographically in 108 human adults aged 19 years and above, 18 infants and children aged 1-18 years (Hamann-Todd Osteological Collection), eight fetuses aged 7-9 months (the Johns Hopkins Collection), and seven nonhuman primates (Hamann-Todd Osteological Collection). In addition, seven documented cases of parents and children were radiographed for genetic evaluation (Osteological Collection of The Hungarian Natural History Museum). Five distinct diploic distribution patterns were identified and described in this study. This was at variance with the impressions reported in dissection-based studies. Independence of diploic vein pattern from demographic (gender and age) and size factors and their tendency to be symmetrical make them amenable and reliable traits for skeletal population study. Diploic vein patterns appeared to be more complicated in humans than in nonhuman primates, raising the possibility of future phylogenetic applications.

The controversy over the reliability of ectocranial suture status (open vs. closed) as an age estimation stimulated the pursuit of Meindl and Lovejoy's suggestion (Meindl and Lovejoy [1985] Am. J. Phys. Anthropol. 68:57-66) for large scale analysis. The extent of the sagittal suture closure was assessed in 3,636 skulls from the Hamann-Todd and Terry collections. The debate over whether cranial suture ossification represents a pathologic or an age-predictable pathologic process also stimulated a comparison with age and two stress markers, hyperostosis frontalis interna and tuberculosis. Sagittal suture closure was found to be age-independent and sexually biased. The wide confidence intervals (for age) appear to preclude meaningful application of suture status for age determination. No correlation was found with the tested biological stressors.

The present study discusses in detail the osteological changes associated with sickle cell anemia in children and their importance in differential diagnosis. Posterior calcaneal and specific articular surface disruptive metacarpal lesions are diagnostic for sickle cell anemia. Calvarial thickening, tibial and femoral cortical bone thickening, and bowing are of more limited utility in differential diagnosis. Granular osteoporosis, pelvic demineralization and rib broadening are nonspecific. Localized calvarial "ballooning," previously not described, may have diagnostic significance. Bone marrow hyperplastic response (porotic hyperostosis) in sickle cell anemia produces minimal radiologic changes contrasted with that observed in thalassemia and blood loss/hemolytic phenomenon. Two other issues, the osteological criteria for discriminating among the anemias and the purported relationship between porotic hyperostosis and iron deficiency anemia, are also discussed. There is sufficient information to properly diagnose the four major groups of anemias, and further, to establish that iron deficiency is only indirectly associated with porotic hyperostosis. The hyperproliferative bone marrow response (manifest as porotic hyperostosis) to blood loss or hemolysis exhausts iron stores, resulting in secondary iron deficiency.

In the present study, 1,869 skulls from the Hamann-Todd Collection were examined (macroscopically and by radiographs) for closure of the petroexoccipital articulation (jugular synchrondrosis). The results demonstrated the the petroexoccipital articulation underwent closure between 20 and 50 years of age in most human skulls evaluated. Approximately 7-10% of the human skulls underwent complete union of the petroexoccipital articulation before 20 years of age. In 5-9% of the population, the joint remained completely open. After 50 years of age, there was no increase in the frequency of individuals with incomplete closure. The frequency of "partial closure" was similar (4-8%) for all age groups (20-25, 30-35, 40-45, 50-55, 60-65, and 70+), excluding the 30-35 year old group (17.5%). The time interval necessary for closure to occur appeared to be very short. No significant differences in closure rates due to ethnic origin, gender, or laterality were noted. The utility of the pteroexoccipital articulation as an age estimator is discussed.

Hyperostosis frontalis interna (HFI) is manifested by the accretion of bone on the inner table of the frontal bone. Despite the vast literature on HFI, ambiguity exists as to its etiology, osteogenesis, demography, and history. This stimulated the present broad-scale study of HFI which included the evaluation of 1,706 early 20th century skulls (1,007 males and 699 females) from the Hamann-Todd and Terry human osteological collections, as well as 2,019 pre-19th century East-Mediterranean, Amerindian, and Central European skulls. In addition, 72 cadavers were dissected for gross inspection and histology. Special attention was paid to the relationship of the brain and meninges to endocranial lesions. HFI is an independent condition, not a symptom of a more generalized syndrome as suggested in the past. It can appear in a variety of forms but each is the result of the same process and probably of the same etiology. Investigators' previous failure to recognize the mild stages of HFI (types A and B) as an early form of the general HFI process led to erroneous statistics and interpretations of observations. HFI should also be considered a phenomenon separate from HCI, hyperostosis cranialis diffusa (HCD), and other endostoses, even when it appears in association with them. To avoid ambiguity and facilitate the description of cranial hyperostoses, uniform nomenclature (HFI, HCD) has been recommended. HFI is rarely seen in historic populations, regardless of geographical origin. It is most commonly found among females and is believed to be associated with prolonged estrogen stimulation. While its magnitude of manifestation and frequency are much higher in females, HFI is not a purely female phenomenon. Males with hormonal disturbances such as atrophic testis were found to manifest HFI type D. HFI is associated with age insofar as it is much less frequent in females under 40 years of age. Although advanced cases of HFI (types C and D) have been observed in individuals as young as 40 years of age, it is more frequently found after age 60. The frequency of HFI type D will not increase from age 60. Type-predicted analysis by cohort reveals significant ethnic differences. Changes in African American (AA) females appear earlier in life and progress more rapidly than in European American (EA) females. Analysis of radiographs shows a discrepancy between the anatomic prevalence of HFI and its radiological recognition, which is very poor for mild cases. This apparently resulted in the misconceptions that HFI is entirely an old-age phenomenon, and that it is exclusively female. Histological analysis shows that the inner table along with the closely attached dural layer play a major role in the osteogenesis of HFI. Contrary to previous models, no evidence for diploe or ectocranial plate involvement was found. Cadaver study suggests that the predilection for the frontal area may be related to an altered blood supply and/or vascular stretching.

This paper describes a phenomenon in the endocranial plate, which we have termed "serpens endocrania symmetrica" (SES), and discusses its value as a diagnostic tool. The affected discolored bone area exhibits disruption of the endocranial surface, lending it a maze-like appearance. Histological sections demonstrate that the process is limited to the most superficial portion of the endocranium, with no diploic and ectocranial involvement (sinus areas excepted). Adult skulls (n = 1,884) from the Hamann-Todd collection (HTH), housed at the Cleveland Museum of Natural History, were utilized for the present study. SES was recognized in 32 of the 1,884 skulls studied (1.7%). The frequency of SES among individuals reported to have died from tuberculosis (TB) was 4.4%. The rate of SES in the non-TB sample was only 0.53%. The locations were as follows: limited to sinus area, 28.1%; calvarium (excluding the sinuses), 46.9%; sinus + calvarium, 25.0%. SES was bilateral in 90.9% of cases. Twenty-five of the 32 individuals (78.1%) with SES in the HTH collection had tuberculosis specifically listed as the cause of death. Six of the other 7 individuals had infections other than TB. In 29 of the 32 individuals with SES, infection involved structures within the thorax. As SES was also associated with another osteological phenomenon known to represent pulmonary disease, i.e., hypertrophic osteoarthropathy (HOA; 68.0% of SES individuals also had HOA), SES may be of diagnostic value in paleopathology for the recognition of intrathoracic disease, and perhaps tuberculosis.

To date, the earliest modern human fossils found outside of Africa are dated to around 90,000 to 120,000 years ago at the Levantine sites of Skhul and Qafzeh. A maxilla and associated dentition recently discovered at Misliya Cave, Israel, was dated to 177,000 to 194,000 years ago, suggesting that members of the Homo sapiens clade left Africa earlier than previously thought. This finding changes our view on modern human dispersal and is consistent with recent genetic studies, which have posited the possibility of an earlier dispersal of Homo sapiens around 220,000 years ago. The Misliya maxilla is associated with full-fledged Levallois technology in the Levant, suggesting that the emergence of this technology is linked to the appearance of Homo sapiens in the region, as has been documented in Africa.

Skeletons of dwarfs have been found in many archaeological sites from around the world. Nevertheless, their descriptions (morphologically and metrically) are very limited. We describe herein the skeleton of a male dwarf, approximately 35–50 years old, found in the Byzantine cemetery (5 th –8 th century CE) of Rehovot-in-the-Negev, southern Israel. Living stature was estimated at 120–125 cm. Detailed morphological skeletal descriptions and morphometric analysis, together with computed tomography (CT) observations, suggest a diagnosis of achondroplasia. The long bones anomalies, in tandem with other features such as hydroceph-alus and spinal stenosis, are discussed in regard to their effect on the dwarf's daily life. The putative place of dwarfs in early Christian communities, compared with dwarfs from other times and places, will be addressed.

Keywords: Levant Early Upper Palaeolithic Aurignacian Manot Cave bone and antler technology Simple-/massive-based projectile points a b s t r a c t The Early Upper Palaeolithic in the Levant plays an important role in understanding the emergence, dispersal, and adaptations of the first Anatomically Modern Human (AMH) populations in the Levant and Europe. The technical exploitation of osseous raw materials, represented by the new concepts applied to the antler working, is recognized as one of several innovations that occur both in the Levant and in Europe during this time. Here we present preliminary results of a technological analysis conducted on the Aurignacian bone and antler industry from the Early Upper Palaeolithic layers of Manot Cave, Israel. The industry displays several similarities with its European counterpart such as the choice of bone for making " domestic " tools (recurrent morpho-types like awls) while antler was used predominantly for hunting equipment (projectile points). The complex technical exploitation of antler, almost exclusively devoted to making hunting weapons, constitutes a major feature both in the European Early Aurignacian and in the Levantine Aurignacian. Nevertheless, while simple-based antler points are common in the Levantine Aurignacian, split-based antler points, characteristic of the European Early Aurignacian are only anec-dotally documented in the Levant. Unique to the Levantine industry is the common exploitation of fallow deer antler. While some of these particularities seem to be related to the different ecological niches exploited, others, such as the different type of hunting weapons, need to be assessed in light of different cultural contexts.

Objectives: Humans display an 85–95% cross-cultural right-hand bias in skilled tasks, which is considered a derived behavior because such a high frequency is not reported in wild non-human primates. Handedness is generally considered to be an evolutionary byproduct of selection for manual dexterity and augmented visuo-cognitive capabilities within the context of complex stone tool manufacture/use. Testing this hypothesis requires an understanding of when appreciable levels of right dominant behavior entered the fossil record. Because bone remodels in vivo, skeletal asymmetries are thought to reflect greater mechanical loading on the dominant side, but incomplete preservation of external morphology and ambiguities about past loading environments complicate interpretations. We test if internal trabecular bone is capable of providing additional information by analyzing the thumb of Homo sapiens and Pan. Materials and methods: We assess trabecular structure at the distal head and proximal base of paired (left/right) first metacarpals using micro-CT scans of Homo sapiens (n 5 14) and Pan (n 5 9). Throughout each epiphysis we quantify average and local bone volume fraction (BV/TV), degree of anisotropy (DA), and elastic modulus (E) to address bone volume patterning and directional asymmetry. Results: We find a right directional asymmetry in H. sapiens consistent with population-level hand-edness, but also report a left directional asymmetry in Pan that may be the result of postural and/ or locomotor loading. Conclusion: We conclude that trabecular bone is capable of detecting right/left directional asymmetry , but suggest coupling studies of internal structure with analyses of other skeletal elements and cortical bone prior to applications in the fossil record.

To examine whether the association between spinal alignment and sacral anatomical orientation (SAO) can be detected in skeletal populations, by comparing SAO values in individuals with a typical SD to individuals with normal spinal alignment. 2025 skeletons were screened for Scheuermann's disease. Scheuermann's kyphosis was established by the presence of apophyseal abnormalities associated with more than 5° of anterior wedging in each of three adjacent vertebrae. SAO was measured as the angle created between the intersection of a line running parallel to the superior surface of the sacrum and a line running between the anterior superior iliac spine and the anterior–superior edge of the symphysis pubis (PUBIS). SAO was measured on 185 individuals with normal spines and 183 individuals with Scheuermann's kyphosis. Out of 2025 skeletons, 183 (9 %) were diagnosed with Scheuermann's kyphosis. The sacrum was significantly more horizontally oriented in individuals with Scheuermann's kyphosis compared with the control (SAO: 44.44 ± 9.7° vs. 50 ± 9.9°, p < 0.001). Alteration in spinal biomechanics due to a horizontally orientated sacrum may be an important contributing factor for the development of Scheuermann's kyphosis.

Study Design. This cross-sectional study was carried out on 196 adults (98 men and 98 women), aged between 18 and 91 years. Objective. To examine whether vertebral hemangiomas (VHs) are associated with other spinal pathologies, metabolic diseases, cardiovascular diseases, cancer and past trauma, to shed light on their possible pathophysiology. Summary of Background Data. VHs are the most common form of benign tumors in the spine. Their association with spinal and systemic pathologies has not yet been systematically studied. Methods. Clinical data were gathered from full spine CT scans and medical records. Results. VHs were significantly associated with disc lesions (P ¼ 0.004), past trauma (P ¼ 0.037), diabetes (x 2 ¼ 5.179, P ¼ 0.023), cardio-vascular diseases (x 2 ¼ 8.625, P ¼ 0.003), and cancer (x 2 ¼ 5.820, P ¼ 0.016), but not with obesity. Only medium-large size VHs were significantly associated with osteoporosis (x 2 ¼ 6.695, P ¼ 0.010). Conclusion. The pattern of diseases related to VHs suggests a common cause for VH, namely, a disruption of vascular flow in the microvessels (accompanied by endothelium damage) within the vertebral body, eventually resulting in hypervascularization.

Although Schmorl’s nodes (SNs) are a common phenomenon in the normal adult population, their prevalence is controversial and etiology still debatable. The objective was to establish the spatial distribution of SNs along the spine in order to reveal its pathophysiology. In this study, we examined 240 human skeleton spines (T4-L5) (from the Hamann–Todd Osteological Collection) for the presence and location of SNs. To determine the exact position of SNs, each vertebral body surface was divided into 13 zones and 3 areas (anterior, middle, posterior). Our results show that SNs appeared more frequently in the T7-L1 region. The total number of SNs found in our sample was 511: 193 (37.7%) were located on the superior surface and 318 (62.3%) on the inferior surface of the vertebral body. SNs were more commonly found in the middle part of the vertebral body (63.7%). No association was found between the SNs location along the spine and gender, ethnicity and age. This study suggests that the frequency distribution of SNs varies with vertebra location and surface. The results do not lend support to the traumatic or disease explanation of the phenomenon. SNs occurrences are probably associated with the vertebra development process during early life, the nucleus pulposus pressing the weakest part of the end plate in addition to the various strains on the vertebrae and the intervertebral disc along the spine during spinal movements (especially torsional movements).

s u m m a r y This paper follows the dramatic changes in scientific research during the last 20 years regarding the relationship between the Mycobacterium tuberculosis complex and its hosts e bovids and/or humans. Once the M. tuberculosis and Mycobacterium bovis genomes were sequenced, it became obvious that the old story of M. bovis evolving into the human pathogen should be reversed, as M. tuberculosis is more ancestral than M. bovis. Nevertheless, the timescale and geographical origin remained an enigma. In the current study human and cattle bone samples were examined for evidence of tuberculosis from the site of Atlit-Yam in the Eastern Mediterranean, dating from 9250 to 8160 (calibrated) years ago. Strict precautions were used to prevent contamination in the DNA analysis, and independent centers used to confirm authenticity of findings. DNA from five M. tuberculosis genetic loci was detected and had characteristics consistent with extant genetic lineages. High performance liquid chromatography was used as an independent method of verification and it directly detected mycolic acid lipid biomarkers, specific for the M. tuberculosis complex. These, together with pathological changes detected in some of the bones, confirm the presence of the disease in the Levantine populations during the Pre-pottery Neolithic C period, more than 8000 years ago.

Two modest seasons of excavation at Kfar HaHoresh in the Lower Galilee , Nazareth Hills have revealed a small I 0 dunam settlement attributable to the middle phase of the PPNB. Mechanically excavated test trenches and subsequent systematic excavations in three areas along trench I on the modest north-facing slope revealed a series of large lime plaster floored quadrilateral sructures, with fieldstone wall foundations, 60-120 em wide. In the middle area, these architectural features appear to be primarily domestic in nature, and include several distinct phases. Subsidiary installations and features include hearths and pits. In the upper and lower areas of the excavation plaster floors ~verlie human and animal interments. demonstrating the existance of highly rituallistic burial customs. The chipped lithic assemblages recovered from the excavations provide evidence con' cerning several distinct reduction sequences. Sickle blades, burins and projectile points, the latter including Amuq points made with Abu Gosh pressure retouch, are notable. Bifacials are rare. Borers and other perforators form a major element of the assembalge. Small assemblages of ground stone tools and of marine molluscs were recovered. The faunal assemblage is dominated by wild, hunted species, especially gazelles, auroch, wild boar as well as goats. The material culture remains are consistent with a date in the first half of the 9th millenium BP, and comparisons with the nearby site of Yiftahel appear most relevant. • In light of the unique and hitherto undocumented ourial practices it would appear that in addition to daily domestic functions, the PPNB settllement at Kfar HaHoresh fulfilled a major ritual role in the area. 74

The use of bone fragments to retouch stone tools is presently recognised as a widespread phenomenon in the Palaeolithic of Europe, since Middle Pleistocene times. However, in the Palaeolithic record outside Europe, evidence for the use of retouchers is scarce. With the sole exception of the late Lower Palaeolithic site of Qesem Cave (Israel), virtually no retouchers have been recognised in the Levant region. Here, we present the first evidence of this type of tool documented for the early Upper Palaeolithic of Manot Cave, western Galilee, Israel. Subsequently, we discuss the absence of retouchers in other Middle and Upper Pal-aeolithic sites in the Levant, and suggest that either Levantine hominins did not habitually use bone retouch-ers, or researchers working in the Levant have not yet identified them as such.